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KMID : 0381219880200020256
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Journal of RIMSK
1988 Volume.20 No. 2 p.256 ~ p.261
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Effect of Nitroglycerin Patch on the transcutaneous Oxygen Tension and the Survival Rate of Skin Flaps in Rabbits
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Kim, Woo Seob
Yoon, Byung Ihl/Kim, Seung Hong/Min, Dae Hong
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Abstract
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One of the most important tasks with which plastic surgeons are concerned in flap surgery is to increase survival rate of the flap and salvage the danger of imminent necrosis. Among various proposals, local application of dimethyl sulfoxide" thymoxamine´,´> phenoxybenzamine and guanethidine°´ isoxuprines´ and phentolamine" are reported to have increased survival as vasodilators.
Nitroglycerin ointment" is recently introduced as a new vasodilator with local application on the flap surface. Nitroglycerin is a well-known vasodilator which has been widely used for pain relief of angina pectoris patient, and more easily applicable patch form of it is developed these days.
So, applying nitroglycerin patch (Deponit-5) on the rabbit skin, authors have measured transcutaneous PO2 tension of normal rabbit skin and flaps in order to investigate the effect of nitroglycerin on flap survival rate.
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